By R. Benito. Western Washington University. 2018.
These dosages also apply to the treatment of pneumonia discount confido 60caps mastercard mens health best, which will be discussed in Section 35 confido 60 caps amex prostate walgreens. Age (weight) Co-trimoxazole (give twice per day for ve days) Amoxicillin (give three times per day for ve days) Adult tablet Paediatric tablet Syrup Syrup(125mg/5ml) (80 mg trimethoprim + (20mgtrimethoprim+ (80mgtrimethoprim+ 400 mg 100 mg 400 mg sulphamethoxazole) sulphamethoxazole) sulphamethoxazole /5 ml) 2 12 months tablet 2 tablets 5 ml (1 teaspoon) 5 ml (1 teaspoon) (4 10 kg) 12 months to 5 1 tablet 3 tablets 7. If the pus continues to discharge from the ear after ve days, refer the child to a health centre for further assessment and treatment. In most cases, the tonsils are affected and become inamed and ulcerated (tonsillitis). In this section, we will describe the clinical manifestations, complications and treatment of pharyngitis. A better understanding of these points will help you to identify a child with pharyngitis and know that you should refer them to a higher level health facility. Pharyngitis can be caused by viruses or bacteria, but the most important causes are bacteria of the type known as Group A Streptococci. Library for the Health Sciences, The immune system recognises Group A Streptococci as foreign and University of Iowa, accessed produces antibodies that attack the bacteria. However, in rare cases, the antibodies produced to ght 36 Study Session 35 Acute Respiratory Tract Infections Group A Streptococci can attack the heart muscle of the infected child. Early diagnosis and If you identify children with correct treatment greatly improve the outcomes and reduce the risk of pharyngitis, you should refer complications. Pharyngitis due to Group A Streptococci should be treated by them to the nearest health doctors using a drug called Benzathine penicillin. This drug is given in the centre or hospital for specialised form of an injection, which is not authorised for use at Health Post level. The lungs are made up of small sacs called alveoli, which are lled with air when a healthy person breathes in. When an individual has pneumonia, the alveoli are lled with pus and uid, which makes breathing painful and limits the amount of oxygen they can take into the body. Pneumonia is caused by a number of infectious agents, mainly by certain bacteria and viruses (Box 35. Haemophilus inuenzae type b (Hib) the second most common cause of bacterial pneumonia. Pneumonia is the number one cause of death among children in Ethiopia and worldwide: globally, it causes an estimated 1. Airborne droplets spread when the sick person coughs or sneezes, and inhaled into the lungs (breathed in) by a susceptible person;. During or shortly after birth, babies are also at higher risk of developing pneumonia from coming into contact with infectious agents in the birth canal, or from contaminated articles used during the delivery. These modes of transmission help to explain why certain risk factors increase the probability that children or adults will develop pneumonia. Under-nutrition/malnutrition, which weakens the immune system and reduces resistance to infection. Inadequate breastfeeding or formula feeding of infants under six months old, which predisposes them to malnutrition and infection. Lack of immunization against vaccine-preventable diseases that affect the respiratory system. Exposure to indoor air pollution, especially smoke from cooking res burning vegetable and animal waste (e. Children who have bacterial pneumonia usually become severely ill and show the following symptoms:. This classication is very important because it determines what treatment is given to the patient (as you will see in Section 35. Presence of general danger signs (unable to drink or eat, lethargic or A child with fast breathing, chest unconscious) in-drawing or stridor should be immediately referred to hospital. You should refer all patients with severe pneumonia immediately to the nearest health centre or hospital, where appropriate drugs Infants less than two months old can be prescribed by doctors or health ofcers. Here we remind you of the oral antibiotics you can give children with non-severe pneumonia without any other danger signs. The course of treatment is for ve days with either co-trimoxazole (the preferred antibiotic drug), or if co-trimoxazole is not available, give amoxicillin. The doses of co-trimoxazole or amoxicillin depend on the age or weight of the child, and were summarised earlier in Table 35. What dose of co-trimoxazole syrup would you give this child, and for how many days? If any of your non-severe patients She is between 12 months and ve years, so you should give her 7. You need to know about them so you can teach members of your community how they can protect their children and vulnerable adults from acute otitis media, pharyngitis and pneumonia. Control measures, such as the treatment or isolation of cases, are applied after the occurrence of the disease, with the aim of reducing the transmission of the infectious agents to new susceptible people. Feeding children with adequate amounts of varied and nutritious food to keep their immune system strong. Avoiding irritation of the respiratory tract by indoor air pollution, such as smoke from cooking res; avoid the use of dried cow dung as fuel for indoor res. Haemophilus inuenzae type b (Hib) vaccine at 6, 10 and 14 weeks; The dosages, schedules and Hib is one of the ve vaccines in the pentavalent vaccine used in vaccination routes for Hib, Ethiopia.
Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness confido 60 caps with visa prostate cancer under 50. Potentially fatal asthma and asthma deaths: knowledge is greater but implementation appears problematic cheap 60caps confido overnight delivery prostate cancer 7 out of 10. The eosinophilic leukocyte and the pathology of fatal bronchial asthma: evidence for pathologic heterogeneity. Triggering the induction of myofibroblast and fibrogenesis by airway epithelial shedding. Functional characteristics of bronchial epithelium obtained by brushing from asthmatic and normal subjects. Associations between asthma history, atopy and non-specific bronchial responsiveness in young adults. Elevated levels of eosinophil granule major basic protein in the sputum of patients with bronchial asthma. Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Psychological defenses and coping styles in patients following a life-threatening attack of asthma. Measuring childhood asthma prevalence before and after the 1997 redesign of the national health interview survey-United States. The risk of asthma attributable to occupational exposures: a population-based study in Spain. Increasing asthma mortality in Denmark 1969 88 not a result of a changed coding practice. Changing patterns of asthma mortality: identifying target populations at high risk. Health service use by African Americans and Caucasians with asthma in a managed care setting. Changing asthma mortality and sales of inhaled bronchodilators and anti-asthmatic drugs. Use of a pharmacy and medical claims database to document cost centers for 1993 annual asthma expenditures. Living histamine containing cells from the bronchial lumens of humans: description and comparison of histamine content with cells of rhesus monkeys. Sudden-onset fatal asthma: a distinct clinical entity with few eosinophils and relatively more neutrophils in the airway submucosa? Clinical, pathologic, and toxicologic findings in asthma deaths in Cook County, Illinois. The effect of airway epithelium on smooth muscle contractability in bovine trachea. Airway hyperresponsiveness in asthma: not just a problem of smooth muscle relaxation with inspiration. The shape of the dose response curve to histamine in asthmatic and normal subjects. Application of density gradient methods for the study of mucus glycoprotein and other macromolecular components of the sol and gel phases of asthmatic sputa. Relationship between airway obstruction and respiratory symptoms in adult asthmatics. Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the inhalation of antigen specific bronchoconstriction. Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of whole lung tissue. Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Routine chest radiographs in exacerbations of chronic obstructive pulmonary disease: Diagnostic value. Sinusitis in adults and its relation to allergic rhinitis, asthma and nasal polyps. Atrial natriuretic peptide concentrations and pulmonary hemodynamics in patients with pulmonary artery hypertension. Airways obstruction in patients with long-term asthma consistent with `irreversible asthma. Evaluation of airways in obstructive pulmonary disease using high-resolution computed tomography. Death due to asthma: new insights into sudden unexpected deaths, but the focus remains on prevention. Investigation of a cluster of deaths of adolescents from asthma: evidence implicating inadequate treatment and poor patient adherence with medications. A reappraisal of the United Kingdom epidemic of fatal asthma: can general mortality data implicate a therapeutic agent?
The epidemic may continue to spread through faecal matter passing from person to person purchase confido 60 caps overnight delivery prostate cancer mayo clinic, if the people in the affected community do not improve their standards of personal hygiene quality 60 caps confido mens health protein, or if the water is not treated and made safe to drink. It is also used to identify the people affected, the circumstances and mode of spread of the disease, and other relevant factors involved in propagating the epidemic. This is especially important if the epidemic has unusual features, if it presents a signicant threat to public health, and it is not self-limiting (i. The main purpose of epidemic investigation is to control the spread of the disease before it causes more deaths and illness. As a Health Extension Practitioner, the rst action you should take is to conrm the existence of an epidemic. To do this, you need to know the average number of cases of that disease during this specic month in your community in previous years, so you can compare that number with the current number of cases. Is there an excess number of cases or deaths from this disease compared to the usual occurrence? If there really are excess cases, you should report your ndings to the District Health Ofce immediately. These steps include conrming the cause (the infectious agent involved), the number of people affected (the cases) and the modes of transmission of the infection from cases to new susceptible hosts. Health professionals at higher levels will require your help in any measures needed to control the spread of the disease, such as giving drugs to people in the community and providing health education. As mentioned above, you may be involved in the management of an epidemic once it is conrmed by the health authorities. The type of control measures you need to implement depend on the type of infectious agent, how the disease is transmitted, and any other factors contributing to the disease. Generally, your control measures should target the infectious agent, the source of any infection, and the treatment of those who became ill. Remember, the source of infection could be humans or animals, or non-living things in the environment. If it is caused by contaminated water, you should educate them not to drink the water until it is treated with chlorine. If mosquito breeding sites are the source of a malaria epidemic, you will need to teach the community to clear the breeding sites for mosquitoes. Summary of Study Session 42 In Study Session 42, you have learned that: 1 An epidemic is the occurrence of more cases of a disease than would be expected in the population at that period of time. Your role as a Health Extension Practitioner is to report the occurrence of an epidemic, to mobilise and educate the community, and to assist the District Health authorities in carrying out control and prevention measures as required. Infection can be transmitted to susceptible members of the community in several ways: via unwashed hands after defaecation, working or playing in the soil; unwashed or inadequately cooked fruit and vegetables grown in contaminated soil; and via ies crawling on faeces and then landing on food, utensils or hands. This is why he appears lethargic, his eyes are sunken, and his skin doesn t go back quickly when pinched. These measures will reduce the indirect transmission of faeco-oral diseases by contaminated water. The characteristic manifestations of cholera are voluminous rice-water diarrhoea and vomiting but not bloody diarrhoea. Ask the patient sfamily members and neighbours about the presence of other individuals with a similar illness, and advise all contacts of the patient to apply thorough hygiene measures, including handwashing with soap and water. Make sure they control the spread of the infectious agents by boiling or disinfecting clothes, bedding or utensils used by the patient; these articles must not be washed in water sources used for bathing or drinking. But the mother should be advised to go on breastfeeding as much as the child will drink, and feed other nourishing food and drinks with a very clean cup and spoon. She should wash her hands frequently and thoroughly with soap, particularly after changing the infant s nappy (diaper) or cleaning its bottom. Tell her she must bring the child back to see you immediately, or take it to the nearest health centre or hospital, if its diarrhoea persists or gets worse. You should treat the ve-year-old child with 1 tablet of albendazole (400 mg) or 1 tablet of mebendazole (500 mg) to be taken orally. Using latrines, safe disposal of faeces, and avoiding open defaecation in elds prevents contamination of soils with faeces containing the worm eggs. Amoebiasis is more common in young adults, but shigellosis is more commoninchildrenbelowtenyears. Amoebiasis is an endemic disease that rarely causes an epidemic, whereas shigellosis (though also endemic) can rapidly spread and cause an epidemic. The bloody diarrhoea in amoebiasis contains some formed stools, but in shigellosis only blood and mucus comes out when the patient strains to defaecate. A patient with amoebiasis is rarely ill enough to remain in bed, whereas someone with shigellosis may be bedridden due to severe dehydration. Prevention and control measures that are common to both diseases are use of latrines, safe disposal of faeces, and avoiding open defaecation in elds. Another similarity is that routine deworming of children aged two to ve years every six months with albendazole or mebendazole reduces the reservoir of both diseases in the community. Prevention and control measures for ascariasis involve prevention of hand-to-mouth transmission of the infectious agents, and avoiding contamination of food and drinking water. In addition, to the measures described in (a), prevention and control measures for hookworm include wearing shoes. Therefore, the man should be referred to a health centre or hospital immediately for further assessment and specialised treatment. A 40-day-old child with fast breathing should be immediately referred to a hospital or health centre for treatment.
As discussed in detail in following sections of this report discount confido 60caps with mastercard man health georgia erectile dysfunction gallery, the first stage in developing this Knowledge Network would involve creating an Information Commons containing a combination of molecular data generic 60 caps confido with amex mens health 28 day fat torch review, medical histories (including information about social and physical environments), and health outcomes for large numbers of individual patients. The Committee envisions this stage occurring in conjunction with the ongoing delivery of clinical care to these patients, rather than in specialized settings specifically crafted for research purposes. The second stage, the construction of the Knowledge Network itself, would involve data mining of the Information Commons and integration of these data with the scientific literature specifically with evolving knowledge of the fundamental biological mechanisms underlying disease. Such a Knowledge Network of Disease would enable development of a more molecularly-based taxonomy. This New Taxonomy could, for example, lead to more specific diagnosis and targeted therapies for muscular dystrophy patients based on the specific mutations in their genes. In other cases, it could suggest targeted therapies for patients with the same genetic mechanism of disease despite very different clinical presentations. Most users would interact with these resources at the higher-value-added levels, the Knowledge Network and the New Taxonomy, rather than at the level of the underlying Information Commons. Validated findings that emerge from the Knowledge Network of Disease and are shown to be useful for defining new diseases or subtypes of diseases that are clinically relevant (e. In contrast, data in each of the higher layers of the Information Commons will overlay on the patient layer in complex ways (e. The Knowledge Network of Disease would allow researchers hypothesize new intralayer cluster and interlayer connections. Validated findings that emerge from the Knowledge Network, such as those which define new diseases or subtypes of diseases that are clinically relevant (e. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 17 Rationale and Organization of the Report Today, historic forces are transforming biomedical research and health care. A Knowledge Network of Disease could embrace and inform rapidly expanding efforts by the biomedical research community to define at the molecular level the disease predispositions and pathogenic processes occurring in individuals. This network has the potential to play a critical role across the globe for the public-health and health-care-delivery communities by enabling development of a more accurate, molecularly-informed taxonomy of disease. This report lays out the case for developing such a Knowledge Network of Disease and associated New Taxonomy. This chapter also addresses the impediments that need to be overcome and changes in medical education that will be required before the Knowledge Network of Disease and resulting New Taxonomy can be expected to achieve their full potential for improving human health. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 2 Why Now? Key enablers of this opportunity include: x New capabilities to compile molecular data on patients on a scale that was unimaginable 20 years ago. Scientific research, information technology, medicine, and public attitudes are all undergoing unprecedented changes. Biology has acquired the capacity to systematically compile molecular data on a scale that was unimaginable 20 years ago. Diverse technological advances make it possible to gather, integrate, analyze, and disseminate health-related biological data in ways that could greatly advance both biomedical research and clinical care. Meanwhile, the magnitude of the challenges posed by the sheer scientific complexity of the molecular influences on health and disease are becoming apparent and suggest the need for powerful new research resources. All these changes provide an opportunity for the biomedical science and clinical communities to come together to improve both the discovery of new knowledge and health-care delivery. The National Human Genome Research Institute estimated that the total cost of obtaining a single human-genome sequence in 2001 was $95 million (Wetterstrand 2011). Costs subsequently dropped exponentially following a trajectory described in electronics as Moore s Law, connoting a reduction of cost by 50 percent every two years, until the spring of 2007, at which point the estimated cost of a single human-genome sequence was still nearly $10 million. The cost is still dropping rapidly, with a $1000 genome becoming a realistic target within a few years. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 21 While whole-genome sequencing remains expensive by the standards of most clinical laboratory tests, the trend-line leaves little doubt that costs will drop into the range of many routine clinical tests within a few years. Whole-genome sequencing will soon become cheaper than many of the specific genetic tests that are widely ordered today and ultimately will likely become trivial compared to the cost of routine medical care. Instead, the clinical utility of genome sequences and public acceptance of their use will drive future developments. These technologies will make it possible to monitor and ultimately to understand and predict the functioning of complex molecular networks in health and disease. The Opportunity to Integrate Data-Intensive Biology with Medicine Human physiology is far more complex than any known machine. The molecular idiosyncrasies of each human being underlie both the exhilarating potential and daunting challenges associated with personalized medicine. Individual humans typically differ from each other at millions of sites in their genomes (Ng et al. More than ten thousand of these differences are known to have the potential to alter physiology, and this estimate is certain to grow as our understanding of the genome expands. All of this new genetic information could potentially improve diagnosis and treatment of diseases by taking into account individual differences among patients. We now have the technology to identify these genetic differences and, in some instances, infer their consequences for disease risk and treatment response. Some successes along these lines have already occurred; however, the scale of these efforts is currently limited by the lack of the infrastructure that would be required to integrate molecular information with electronic medical records during the ordinary course of health care. The human microbiome project represents an additional opportunity to inform human healthcare. The microorganisms that live inside and on humans are estimated to outnumber human somatic cells by a factor of ten. The ultimate goal of studying the human microbiome is to better understand the impact of microbial variation across individuals and populations and to use this information to target the human microbiome with antibiotics, probiotics, and prebiotics as therapies for specific disorders.